Cladosporium sphaerospermum has a worldwide distribution. It is a leaf mould (phylloplane) commonly isolated from air, soil, foodstuffs, paint and textiles. It is also very common on wet building material such as gypsum board, acrylic and soil painted walls, painted wood, and wallpaper; carpet and mattress dust; HVAC fans, and wet insulation in mechanical cooling units.
Cladosporium sphaerospermum is allergenic, i.e., its spores can elicit allergic reactions to susceptible individuals. In the medical literature, Cladosporium sphaerospermum has been implicated as the cause of human corneal ulcer, skin lesions and infection of nails.
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Species of Trichoderma are very common in soil and cellulolytic materials including decaying wood, wood products, textiles, stored cereals and plant foodstuffs. Many species are strongly cellulolytic (i.e., they are capable of degrading cellulose since they produce large quantities of the enzyme cellulase). For this reason, they are important spoilage organisms and also cause post-harvest rots of various fruits and vegetables. They are also important producers of antibiotics and they have been researched extensively for biological control, especially of wood-rotting fungi.